Argireline for Skin: Benefits and How to Use

To eliminate dynamic wrinkles (wrinkles caused by repetitive muscle movement – think crow’s feet around the eyes or 11 points between the eyebrows), injectable neurotoxins (Botox, Dysport, Juveau) are the obvious choice.

By paralyzing the muscles, they prevent them from moving – and the wrinkles disappear. But what if you don’t want to go through the acupuncture treatment?

Argireline is a synthetic peptide that has a variety of potential anti-wrinkle and anti-aging benefits. According to experts, its effectiveness is so high that it is the closest treatment to Botox.

Experts tell you all about this great skin-smoothing product.

Hexapeptide

Ingredient type: Peptide

Key benefits: Prevents wrinkle-causing muscle movement. Argireline also boosts collagen production and optimizes collagen function, which fights fine lines and improves skin hydration levels, Shah says.

For: Anyone who wants to smooth wrinkles caused by repetitive muscle movement in areas such as the forehead and around the eyes. It’s also a good choice for people with dry skin, as it promotes hydration in the application area.

How often to use: Can be used daily.

Works well with: One study showed that it works well with another peptide, tripeptide-10-citrulline.

This increases Argireline’s ability to penetrate deeper into the skin and target wrinkle-causing muscles. 1 It’s also often combined with hyaluronic acid to enhance moisturizing effects.

Do not use with: Generally speaking, Argireline is compatible with all ingredients.

What is Argireline?

Argireline is simply the brand name for a specific peptide, acetyl hexapeptide-3 (also known as acetyl hexapeptide-8).

Remember, peptides are short chains of amino acids that are the building blocks of proteins like collagen and elastin, and are therefore essential for healthy, youthful skin, says Shah.

While peptides of all kinds are common in skincare, this one differs in its ability to reduce muscle movement and associated wrinkles; Shah notes that it’s the first peptide with a targeted effect on expression lines.

“Everyone is trying to emulate a competitor to Botox, and Argireline is one of the best candidates so far,” adds Linkner. Argireline is a peptide that affects neuromuscular communication, preventing muscles from fully contracting, she explains.

In addition to its muscle-relaxing effects, it stimulates collagen production, which results in smooth, wrinkle-free skin. 2

A few things to note when using Argireline in skincare: Since it’s a brand name, only one lab in Spain holds the patent for the peptide. The company licenses its use to individual brands, who often combine it with other anti-aging ingredients, Linkner says.

Second, each product’s formulation determines its effectiveness: “Just because a product has hexapeptide doesn’t necessarily mean it’s effective. The formula itself, as well as the size of the peptide, affects how deeply it penetrates the skin,” Bae says.

When looking for a product, choose one that’s alcohol-free, especially if you have dry skin. “Argireline has a difficult formula, and some companies mix the ingredient with alcohol, which negates its moisturizing effects,” Shah notes.

Benefits of Argireline for Skin

For ultimate wrinkle control, choose this peptide, which can fight annoying fine lines and wrinkles in a variety of ways.

Prevents the formation of dynamic wrinkles: “Argireline works very specifically on the protein receptor complex that promotes muscle movement,” explains Bae. This means it blocks nerves from communicating with the muscles and signaling them to contract—the less muscle contraction, the fewer wrinkles.

Stimulates collagen production: By increasing the production of collagen (the protein responsible for firm, healthy skin), it also prevents the formation of fine lines and wrinkles.

Helps the skin retain moisture: Argireline also optimizes collagen function, which, in addition to having a skin-smoothing effect, also increases the skin’s moisture levels, Shah says. And hydrated skin always looks younger than dry skin.

Side effects of Argireline

Generally, there are no known side effects to this ingredient. 4 If you want to be on the safe side, you can test it on a small area for a few days to make sure you’re not allergic to it.

Application

This peptide is best used in targeted applications on areas with deep wrinkles or fine lines caused by repetitive muscle movement—fine lines around the eyes, the “11” between the eyebrows, and forehead wrinkles are ideal areas.

Since the final formula of each product can vary greatly, follow the product instructions to determine how often to use.

Best Products with Argireline

The Ordinary Buffet

As its name suggests, this serum uses a blend of real peptides, including Syn-ake, Matrixyl Synthe-6, and Matrixyl 3000, in addition to Argireline, and according to Shah, he also appreciates the hyaluronic acid and amino acids in it.

“It’s suitable for a variety of skin types, and it contains no parabens or alcohol,” he adds. Another positive: The price is very, very reasonable.

Instant Eternity

Also known as the “facelift in a box,” this product has wowed Byrdie editors for its ability to tighten wrinkles and reduce eye bags. And thanks to Argireline, it promises to produce results almost immediately, so you can see the results for yourself.

DermaE Advanced Peptide and Collagen Moisturizer

In addition to the peptide combo, including Argireline, this treatment also contains the powerful antioxidants Pycnogenol (pine bark extract), vitamin C, and green tea. The rich, hydrating texture makes it an ideal nighttime moisturizer.

It’s no surprise that dermatologists often recommend this brand because its products are affordable and effective.

Hydroxatone AM/PM Anti-Wrinkle Complex SPF 15

This multi-functional moisturizer is suitable for both daytime and nighttime use. Argireline is combined with Matrixyl 3000, another peptide known for its anti-wrinkle properties, to smooth fine lines. Hyaluronic acid hydrates and plumps the skin.

The Ordinary Hexapeptide Solution 10%

According to Linkner, this pure Argireline serum is a promising topical alternative to Botox knockoffs. A Byrdie editor also named it one of the brand’s top picks—apply it around the eyes and on the forehead morning and night before applying other products.

Peter Thomas Roth Super-Nourishing Anti-Aging Cellular Eye Cream

Four different peptides, including Argireline, are uniquely formulated to combat crow’s feet around the eyes. Retinol further enhances the smoothing effect while providing intensive hydration and nourishment—perfect for combating dryness on sensitive skin.

Estée Lauder Perfectionist Pro Instant Wrinkle Filler Triple Polymer Blend

Since Argireline is a top ingredient specifically designed to target expression lines 7, it’s recommended to be used in products specifically targeting stubborn fine lines and wrinkles.

The filling spheres provide an immediate smoother skin appearance (an instant reward for success), while the peptides boost collagen production.

FAQ

When should I use Argireline in my skincare routine?

Argireline can be added to a variety of skin care products. Therefore, application depends on the type of product. However, if you use Argireline serum, you can incorporate it into your daily daytime and nighttime care routine after cleansing your face.

How long do the effects of Argireline last?

An early study in 2002 found that when Argireline was used once a day for 30 days, wrinkles could be reduced by up to 30%. 8

Will Argireline damage the skin?

Unlike Botox, Argireline is not a toxin. It is a peptide that will not harm the skin or cause side effects.